About Prion-Priority Project

PRIORITY: a EU-funded research effort aimed at understanding prions and protecting citizens from Europe and elsewhere from them

Protecting the food chain from prions: shaping European priorities through basic and applied research (PRIORITY)

Funded under 7th FWP (Seventh Framework Programme)

 

 

 

Research area: KBBE-2007-2-4-06 Protecting animal and human health from prions in food, feed and the environment

 

Coordinator:

Jesús R. Requena,

Universidade de

Santiago de Compostela

Contact Person:

CACHEIRO MARTINEZ, Martin (Mr)
Tel: +34-981-547050
Fax: +34-981-528019
Email: Contact

Organisation:

UNIVERSIDADE DE
SANTIAGO DE COMPOSTELA
Pazo de San Xerome

Praza do Obradoiro
Santiago de Compostela

SPAIN

 

Project description

Bovine Spongiform Encephalopathy (BSE) started, 20 years ago, a devastating health and food crisis throughout Europe. Classical BSE is now under control as a result of the meat and bone meal ban. However, tonsil analyses suggest that there may be an alarmingly high number of asymptomatic PrPSc positive cases. Transmission through blood transfusion is another important concern, as are recent atypical cases of BSE.

Only a profound understanding of the molecular biology of prions will enable us to control them. Thus, to understand why BSE-contaminated food causes vCJD, we need to understand how prions get into food, what happens with them in the gut, how they reach the brain, and how they initiate the chain reaction rapidly leading to death. We have formulated 7 key questions:
* How can we avoid a new BSE outbreak, or other possible future prion infection of livestock?
* Why did decontamination of meat and bone meal fail; is there an effective way to decontaminate feedstuffs, soil etc?
* What is the risk of humans being infected with each of the different prion strains known thus far?

* Which are the best strategies to implement feasible prion eradication programs?

* How can we develop a pre-clinical prion blood test?

* How can we identify human cases with potential secondary transmission?* What is the origin of atypical human CJD cases?

 

We will search for decisive data on the structure of PrPSc, the molecular basis of strains and species barriers, the mechanism of prion conversion, the cell biology of PrPSc, the function of PrPC, and the mechanisms of PrP-associated pathology. This information will be translated into a better estimation of current exposure risk to humans from TSE, evaluation of current intervention strategies, and development of improved decontamination techniques and prion tests.

 

With all this, we will be able to respond to the questions formulated and thus advise the EC on TSE policy for the protection of European consumers.

 

Project details

Project Acronym: PRIORITY
Project Reference: 222887
Start Date: 2009-10-01
Duration: 48 months
Project Cost: 7.9 million euro
Contract Type: Large-scale integrating project
End Date: 2013-09-30
Project Status: Execution
Project Funding: 6 million euro

 

Participants

PRIONICS AG

SWITZERLAND

SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE

SLOVAKIA

UNIVERSITEIT MAASTRICHT

NETHERLANDS

SMP GMBH - PRUEFEN VALIDIEREN FORSCHEN

GERMANY

FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT

GERMANY

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

FRANCE

STICHTING HET NEDERLANDS KANKER INSTITUUT

NETHERLANDS

INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA

SPAIN

THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS

UNITED KINGDOM

INSTITUT PASTEUR

FRANCE

UNIVERSITAET ZUERICH

SWITZERLAND

UNIVERSITAET HOHENHEIM

GERMANY

UNIVERSITAT DE BARCELONA

SPAIN

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

GERMANY

KAROLINSKA INSTITUTET

SWEDEN

VETERINAERINSTITUTTET - NATIONAL VETERINARY INSTITUTE

NORWAY

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

GERMANY

SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI

ITALY

THE UNIVERSITY OF EDINBURGH

UNITED KINGDOM

THE HEBREW UNIVERSITY OF JERUSALEM.

ISRAEL

Record Control Number: 91977

Update Date: 2009-10-06 09:19:02.0

 

 

 

 

 

Main Links

NeuroPrion
www.neuroprion.org

 
EU research
 
 

University of Santiago
de Compostela